Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia.

Susanna R Var, Phoebe Strell, Sether T Johnson, Alex Roman, Zoey Vasilakos, Walter C Low

Journal: Cell transplantation 2023;32():9636897231171001

PMID: 37254858

Abstract

Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found in many diseases and disorders, such as Alzheimer's disease, Parkinson's disease, and CNS-related injuries, and can accelerate or worsen the condition. Transplantation studies designed to replace and supplement dysfunctional microglia with healthy microglia offer a promising strategy for addressing microglia-mediated neuroinflammation and pathologies. This review will cover microglial involvement in neurological diseases and disorders and CNS-related injuries, current microglial transplantation strategies, and different approaches and considerations for generating exogenic microglia.

Address: Department of Neurosurgery, Medical School, University of Minnesota, Minneapolis, MN, USA.; Stem Cell Institute, Medical School, University of Minnesota, Minneapolis, MN, USA.; Department of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.; Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.

DOI: 10.1177/09636897231171001

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https://medlineplus.gov/neurologicdiseases.html

MeSH Terms: Humans, Microglia, Nervous System Diseases, Central Nervous System, Dietary Supplements, Transplants