Reciprocal regulation of mesenchymal stem cells and immune responses.

Ying Wang, Jiankai Fang, Benming Liu, Changshun Shao, Yufang Shi

Journal: Cell stem cell 2022;29(11):1515-1530

PMID: 36332569

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Abstract

Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for autoimmune diseases, organ failures, and many other chronic disorders. Remarkably, the reparative and homeostatic maintenance functions of MSCs rely on their interaction with the inflammatory microenvironment. Here, we discuss the characteristics and functions of MSCs under different pathophysiological conditions and highlight how the immunomodulatory functions of MSCs are altered in accordance with the inflammatory cues. We hope to provide new insights into the diverse immunoregulatory properties of MSCs during tissue regeneration and therapy.

Address: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; The Third Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China.; The Third Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. Electronic address: [email protected].

DOI: 10.1016/j.stem.2022.10.001

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1934...

Medical:

https://medlineplus.gov/autoimmunediseases.html

MeSH Terms: Humans, Mesenchymal Stem Cells, Immunomodulation, Wound Healing, Autoimmune Diseases, Immunity, Mesenchymal Stem Cell Transplantation