Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition.

Milou S van Driel, Jasmijn D G Linssen, Dustin J Flanagan, Nikola Vlahov, Lisanne E Nijman, Nina E de Groot, Clara C Elbers, Jan Koster, Owen J Sansom, Louis Vermeulen, Sanne M van Neerven

Journal: Cellular and molecular gastroenterology and hepatology 2023;16(4):652-655

PMID: 37364735

Abstract

Address: Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands.; Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands; Amsterdam UMC, Location University of Amsterdam, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia; Cancer Program, Biomedicine Discovery Institute, Monash University, Melbourne, Australia; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.; Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands.; Cancer Research UK Beatson Institute, Glasgow, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.; Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands. Electronic address: [email protected].; Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands; Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom. Electronic address: [email protected].
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