Feto-placental Unit: From Development to Function.

Ambart Covarrubias, Macarena Aguilera-Olguín, Ivo Carrasco-Wong, Fabián Pardo, Pamela Díaz-Astudillo, Sebastián San Martín

Journal: Advances in experimental medicine and biology 2023;1428():1-29

PMID: 37466767

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Abstract

The placenta is an intriguing organ that allows us to survive intrauterine life. This essential organ connects both mother and fetus and plays a crucial role in maternal and fetal well-being. This chapter presents an overview of the morphological and functional aspects of human placental development. First, we describe early human placental development and the characterization of the cell types found in the human placenta. Second, the human placenta from the second trimester to the term of gestation is reviewed, focusing on the morphology and specific pathologies that affect the placenta. Finally, we focus on the placenta's primary functions, such as oxygen and nutrient transport, and their importance for placental development.

Address: Health Sciences Faculty, Universidad San Sebastián, Concepción, Chile.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Group of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, Chile.; Biomedical Research Centre, School of Medicine, Universidad de Valparaíso, Viña del Mar, Chile.; Cellular Signalling and Differentiation Laboratory (CSDL), Medicine and Science Faculty, Universidad San Sebastián, Santiago, Chile.; Cellular Signalling and Differentiation Laboratory (CSDL), School of Medical Technology, Medicine and Science Faculty, Universidad San Sebastián, Santiago, Chile.; Metabolic Diseases Research Laboratory, Interdisciplinary Centre of Territorial Health Research (CIISTe), Biomedical Research Center (CIB), San Felipe Campus, School of Medicine, Faculty of Medicine, Universidad de Valparaíso, San Felipe, Chile.; Biomedical Research Centre, School of Medicine, Universidad de Valparaíso, Viña del Mar, Chile. [email protected].; Group of Research and Innovation in Vascular Health (GRIVAS Health), Chillan, Chile. [email protected].

DOI: 10.1007/978-3-031-32554-0_1

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https://dx.doi.org/10.1007/978-3-031-32554-0_1

MeSH Terms: Pregnancy, Female, Humans, Placenta, Fetus, Placentation, Fetal Development