Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases.

Hong-Yu Liang, Shu-Fang Li, Yong Chen, Ren-Peng Zhou, Wei-Rong Hu, Jie Ding, Ying-Jie Zhao, Chao Lu, Fei-Hu Chen, Wei Hu

Journal: Ageing research reviews 2022;83():101785

PMID: 36371015

Full Text on Elsevier Science View on PubMed

Abstract

Age-related diseases have become more common with the advancing age of the worldwide population. Such diseases involve multiple organs, with tissue degeneration and cellular apoptosis. To date, there is a general lack of effective drugs for treatment of most age-related diseases and there is therefore an urgent need to identify novel drug targets for improved treatment. Acid-sensing ion channel 1a (ASIC1a) is a degenerin/epithelial sodium channel family member, which is activated in an acidic environment to regulate pathophysiological processes such as acidosis, inflammation, hypoxia, and ischemia. A large body of evidence suggests that ASIC1a plays an important role in the development of age-related diseases (e.g., stroke, rheumatoid arthritis, Huntington's disease, and Parkinson's disease.). Herein we present: 1) a review of ASIC1a channel properties, distribution, and physiological function; 2) a summary of the pharmacological properties of ASIC1a; 3) and a consideration of ASIC1a as a potential therapeutic target for treatment of age-related disease.

Address: Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei 230032, China.; The Second School of Clinical Medicine, Anhui Medical University, Hefei 230032, China.; School of Pharmacy, Anhui Medical University, Hefei 230032, China.; Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China.; First Affiliated Hospital, Anhui University of Science & Technology, Huainan 232001, China.; Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei 230032, China. Electronic address: [email protected].

DOI: 10.1016/j.arr.2022.101785

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MeSH Terms: Humans, Acid Sensing Ion Channels, Acidosis, Stroke, Apoptosis, Aging