Vascular calcification in chronic kidney disease: contribution of ferroptosis?

Tilman B Drüeke, Ziad A Massy

Journal: Kidney international 2022;102(6):1209-1211

PMID: 36411014

Full Text on Elsevier Science View on PubMed

Abstract

Vascular calcification associated with chronic kidney disease (CKD) is an active, regulated process. Apoptosis of vascular smooth muscle cells has long been known to play a major role in its pathogenesis, with apoptotic bodies derived from these cells acting as nucleating structures for calcium crystal formation and deposition. Ye et al. now show in experimental models in vitro and in vivo that ferroptosis can also contribute to the development of vascular calcification in CKD.

Address: Inserm U-1018, Centre de recherche en épidémiologie et santé des populations, Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, Université de Versailles Saint-Quentin-en-Yvelines), and Paris Saclay University, Villejuif, France. Electronic address: [email protected].; Inserm U-1018, Centre de recherche en épidémiologie et santé des populations, Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, Université de Versailles Saint-Quentin-en-Yvelines), and Paris Saclay University, Villejuif, France; Department of Nephrology, Ambroise Paré University Hospital, Assistance Publique - Hôpitaux de Paris, Boulogne-Billancourt, Paris, France.

DOI: 10.1016/j.kint.2022.08.031

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MeSH Terms: Humans, Ferroptosis, Vascular Calcification, Renal Insufficiency, Chronic, Myocytes, Smooth Muscle, Apoptosis