A review on the role of NR2F1-AS1 in the development of cancer.

Soudeh Ghafouri-Fard, Mohammad Taheri, Aria Baniahmad, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Majid Samsami

Journal: Pathology, research and practice 2022;240():154210

PMID: 36410172

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Abstract

NR2F1-AS1 is a natural antisense transcript with prominent roles in the carcinogenesis. It acts as an oncogene in almost all types of cancers except for cervical and colorectal cancers. It can act as a molecular sponge for miR-17, miR-371a-3p, miR-363, miR-29a-3p, miR-493-5p, miR-190a, miR-140, miR-642a, miR-363, miR-493-5p, miR-483-3p, miR-485-5p, miR-146a-5p, miR-877-5p, miR-338-3 P and miR-423-5p to influence expression of several cancer-related genes. Thus, the sponging role of NR2F1-AS1 is the most appreciated route of its contribution in the carcinogenesis. In addition, NR2F1-AS1 affects activity of IGF-1/IGF-1R/ERK, PI3K/AKT/GSK-3β and Hedgehog pathways. The current narrative review aims at summarization of the results of studies that highlighted the role of NR2F1-AS1 in the carcinogenesis.

Address: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq; Center of Research and Strategic Studies, Lebanese French University, Kurdistan Region, Erbil, Iraq.; Institute of Human Genetics, Jena University Hospital, Jena, Germany.; Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.prp.2022.154210

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0344...

Medical:

https://medlineplus.gov/cancer.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-2786

MeSH Terms: Humans, Carcinogenesis, COUP Transcription Factor I, Glycogen Synthase Kinase 3 beta, Hedgehog Proteins, MicroRNAs, Neoplasms, Phosphatidylinositol 3-Kinases, RNA, Antisense