The role of ion channels in immune-related diseases.

Ting Zhang, Qi Liu, Zhuo Li, Siqi Tang, Qimin An, Dongdong Fan, Yiwei Xiang, Xianli Wu, Zhe Jin, Jianhong Ding, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie

Journal: Progress in biophysics and molecular biology 2023;177():129-140

PMID: 36417963

Full Text on Elsevier Science View on PubMed

Abstract

Ion channel is an integral membrane protein that allows the permeation of charge ions across hydrophobic phospholipid membranes, including plasma membranes and organelle membranes (such as mitochondria, endoplasmic reticulum and vacuoles), which are widely distributed in various cells and tissues, such as cardiomyocytes, smooth muscle cells, and nerve cells. Ion channels establish membrane potential by regulating ion concentration and membrane potential. Membrane potential plays an important role in cells. Studies have shown that ion channels play a role in a number of immune-related diseases caused by functional defects in ion channels on immune or non-immune cells in major human organs, usually affecting specific organs or multiple organs. The present review discusses the relationship between ion channels and immune diseases in major organs of the human body.

Address: Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.; Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China. Electronic address: [email protected].; Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China. Electronic address: [email protected].

DOI: 10.1016/j.pbiomolbio.2022.11.003

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MeSH Terms: Humans, Ion Channels, Cell Membrane, Organelles, Ions, Immune System Diseases