Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

Address: Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. [email protected].; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. [email protected].; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected].; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected].; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Population Medicine, Qatar University College of Medicine, Doha, Qatar.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.; German Research Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Lübeck, Germany.; Medical Research Council Population Health Research Unit, CTSU-Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, UK.; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Japan.; Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.; HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim, Norway.; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Department of Nutrition-Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.; German Heart Centre Munich, Department of Cardiology, Technical University of Munich, Munich, Germany.; CTSU-Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, UK.; German Research Center for Cardiovascular Research (DZHK e.V.), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Genetics and Genomic Science, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Klinikum Rechts der Isar, Institute of Human Genetics, Technical University of Munich, Munich, Germany.; School of Medicine and University Hospital Bonn, Institute of Human Genetics, University of Bonn, Bonn, Germany.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Internal Medicine, Division of Cardiology, Landspitali-National University Hospital of Iceland, Hringbraut, Reykjavik, Iceland.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.; Cardiovascular Genomics and Genetics, University of Arizona College of Medicin, Phoenix, AZ, USA.; Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Integrated Cardio Metabolic Centre, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.; Clinical Gene Networks AB, Stockholm, Sweden.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital Attikon, Athens, Greece.; Department of Cardiac Surgery, Tartu University Hospital and Institute of Clinical Medicine, Tartu University, Tartu, Estonia.; Harvard T.H.Chan School of Public Health, Boston, MA, USA.; College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, UAE.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; National Institute for Health and Care Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge, UK.; The National Institute for Health and Care Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; Human Genetics, Wellcome Sanger Institute, Saffron Walden, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge, UK.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.; Verve Therapeutics, Cambridge, MA, USA.; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [email protected].; National Institute for Health and Care Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge, UK. [email protected].; The National Institute for Health and Care Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, UK. [email protected].; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. [email protected].; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge, UK. [email protected].