Correlations between single nucleotide polymorphisms in obsessive-compulsive disorder with the clinical features or response to therapy.

Samaneh Mollazadeh, Michael R Hamblin, Mohammad Taghizadieh, Nikta Rabiei, Masoumeh Beheshti, Pariya Eskandari, Ehsan Dadgostar, Arash Salmaninejad, Raziye Emadi, Amir Hossein Mohammadi, Hamed Mirazei

Journal: Journal of psychiatric research 2023;157():223-238

PMID: 36508934

Full Text on Elsevier Science View on PubMed

Abstract

Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder, in which the patient endures intrusive thoughts or is compelled to perform repetitive or ritualized actions. Many cases of OCD are considered to be familial or heritable in nature. It has been shown that a variety of internal and external risk factors are involved in the pathogenesis of OCD. Among the internal factors, genetic modifications play a critical role in the pathophysiological process. Despite many investigations performed to determine the candidate genes, the precise genetic factors involved in the disease remain largely undetermined. The present review summarizes the single nucleotide polymorphisms that have been proposed to be associated with OCD symptoms, early onset disease, neuroimaging results, and response to therapy. This information could help us to draw connections between genetics and OCD symptoms, better characterize OCD in individual patients, understand OCD prognosis, and design more targeted personalized treatment approaches.

Address: Pathophysiology Laboratory, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.; School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Pathology, School of Medicine, Center for Women's Health Research Zahra, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Biology, School of Basic Sciences, University of Guilan, Rasht, Iran.; Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.; Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa.; Regenerative Medicine, Organ Procurement and Transplantation Multi Disciplinary Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: [email protected].; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected].

DOI: 10.1016/j.jpsychires.2022.11.025

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MeSH Terms: Humans, Polymorphism, Single Nucleotide, Obsessive-Compulsive Disorder