Pathogenic role of 25-hydroxycholesterol in cancer development and progression.

Yasser Fakri Mustafa, Moaed E Al-Gazally, Abduladheem Turki Jalil, Ali Thaeer Hammid, Maria Jade Catalan Opulencia, Sura Salman Ejam, Raed Obaid Saleh, Mazin Aa Najm, Aziza Makhmudova, Walid Kamal Abdelbasset, Sergushina Elena Sergeevna, Sajad Karampoor, Rasoul Mirzaei

Journal: Future oncology (London, England) 2023;18(39):4415-4442

PMID: 36651359

Abstract

Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is a cholesterol derivative that may be formed from cholesterol. 25-HC is a crucial component in various biological activities, including cholesterol metabolism. In recent years, growing evidence has shown that 25-HC performs a critical function in the etiology of cancer, infectious diseases and autoimmune disorders. This review will summarize the latest findings regarding 25-HC, including its biogenesis, immunomodulatory properties and role in innate/adaptive immunity, inflammation and the development of various types of cancer.

Address: College of Medicine, University of Babylon, Babylon, Iraq.; Department of Pharmacy, Al-Maarif University College, Al-Anbar, Iraq.; College of Business Administration, Ajman University, Ajman, United Arab Emirates.; Pharmaceutical Chemistry Department, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq.; Department of Social Sciences & Humanities, Samarkand State Medical Institute, Samarkand, Uzbekistan.; Department of Scientific Affairs, Tashkent State Dental Institute, Makhtumkuli Street 103, Tashkent, 100047, Uzbekistan.; Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, 51001, Iraq.; Department of Health & Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia.; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.; College of Medicine, University of Al-Ameed, Karbala, Iraq.; Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja'afar Al-Sadiq University, Baghdad, Iraq.; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.; National Research Ogarev Mordovia State University, 68 Bolshevitskaya Street, Republic of Mordovia, Saransk, 430005, Russia.; Gastrointestinal & Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.; Venom & Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

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