Halomonas spp., as chassis for low-cost production of chemicals.

Guo-Qiang Chen, Xu Zhang, Xu Liu, Weiran Huang, Zhengwei Xie, Jing Han, Tong Xu, Ruchira Mitra, Cheng Zhou, Jing Zhang, Tao Chen

Journal: Applied microbiology and biotechnology 2022;106(21):6977-6992

PMID: 36205763

Full Text on Springer View on PubMed

Abstract

Halomonas spp. are the well-studied platform organisms or chassis for next-generation industrial biotechnology (NGIB) due to their contamination-resistant nature combined with their fast growth property. Several Halomonas spp. have been studied regarding their genomic information and molecular engineering approaches. Halomonas spp., especially Halomonas bluephagenesis, have been engineered to produce various biopolyesters such as polyhydroxyalkanoates (PHA), proteins including surfactants and enzymes, small molecular compounds including amino acids and derivates, as well as organic acids. This paper reviews all the progress reported in the last 10 years regarding this robust microbial cell factory. KEY POINTS: • Halomonas spp. are robust chassis for low-cost production of chemicals • Genomic information of some Halomonas spp. has been revealed • Molecular tools and approaches for Halomonas spp. have been developed • Halomonas spp. are becoming more and more important for biotechnology.

Address: MOE Key Laboratory for Industrial Biocatalysts, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China. [email protected].; School of Life Sciences, Tsinghua University, Beijing, 100084, China. [email protected].; Tsinghua-Peking Center of Life Sciences, Beijing, 100084, China. [email protected].; Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China. [email protected].; MOE Key Laboratory for Industrial Biocatalysts, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.; Tsinghua-Peking Center of Life Sciences, Beijing, 100084, China.; PhaBuilder Biotechnol Co. Ltd. Shunyi District, Zhaoquan Ying, Beijing, 101309, China.; Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Haidian District, Beijing, 100191, China.; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.; International College, University of Chinese Academy of Sciences, 100049, Beijing, People's Republic of China.; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.

DOI: 10.1007/s00253-022-12215-3

Link outs

Free resources

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Miscellaneous:

https://assays.cancer.gov/CPTAC-1612

Subscription / membership required

Full Text Sources:

https://dx.doi.org/10.1007/s00253-022-12215-3

MeSH Terms: Halomonas, Polyhydroxyalkanoates, Biotechnology, Amino Acids, Surface-Active Agents, Metabolic Engineering