Enhancing children's cognitive function and achievement through carotenoid consumption: The Integrated Childhood Ocular Nutrition Study (iCONS) protocol.

Corinne N Cannavale, Shelby A Keye, Laura Rosok, Shelby Martell, Tori A Holthaus, Ginger Reeser, Lauren B Raine, Sean P Mullen, Neal J Cohen, Charles H Hillman, Billy R Hammond, Lisa Renzi-Hammond, Naiman A Khan

Journal: Contemporary clinical trials 2022;122():106964

PMID: 36252934

Free Full Text on PubMed Central View on PubMed

Abstract

Lutein and zeaxanthin (L + Z) are carotenoids that accumulate in neural tissue and potentially confer benefits to cognition. Whereas cross-sectional studies have revealed positive associations between macular carotenoids (MC) and cognition, no studies have investigated whether L + Z supplementation impacts MC and cognition in childhood. Accordingly, the Integrated Childhood Ocular Nutrition Study aims to investigate the impact of L + Z supplementation over 9-months on academic abilities, attentional control, memory, and MC among preadolescent children. Children 8-10 years (N = 288) will enroll in a 9-month double-blind, placebo-controlled, randomized trial. The study is registered and approved as a clinical trial on the U.S. National Library of Medicine http://ClinicalTrials.gov registry (NCT05177679). Participants will be randomized into an active (10 mg lutein+2 mg zeaxanthin) or waitlist placebo-controlled group. Primary outcomes include hippocampal-dependent memory, attentional inhibition, and academic achievement using a spatial reconstruction task, an Eriksen flanker task, and the Kaufman Test of Academic and Educational Achievement 3rd edition, respectively. Secondary outcomes include event-related brain potentials of attentional resource allocation and information processing speed (i.e., P3/P300 amplitude and latency) recorded during the flanker task. Macular pigment optical density (MPOD) will be assessed using heterochromatic flicker photometry. Cognitive assessments will be completed prior to and after completion of the supplementation period. MPOD will be quantified prior to, at the mid-point of (4-5 months), and after (9 months) the supplementation period. It is hypothesized that L + Z supplementation will improve cognition and academic achievement. Further, benefits for cognition and achievement are anticipated to be mediated by increases in MC among treatment group participants.

Address: Department of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.; Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.; Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, United States of America.; Department of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, IL, United States of America; Beckman Institute for the Advancement of Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, United States of America; Illinois Informatics Institute, University of Illinois Urbana-Champaign, Urbana, IL, United States of America; Center for Social and Behavioral Science, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.; Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, United States of America; Department of Psychology, University of Illinois Urbana-Champaign, Urbana, IL, United States of America; Interdisciplinary Health Sciences Institute, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.; Department of Psychology, Northeastern University, Boston, MA, United States of America; Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, United States of America.; Department of Psychology, University of Georgia, Athens, GA, United States of America.; Department of Psychology, University of Georgia, Athens, GA, United States of America; College of Public Health, University of Georgia, Athens, GA, United States of America.; Department of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, IL, United States of America; Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, United States of America; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States of America; Beckman Institute for the Advancement of Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, United States of America. Electronic address: [email protected].

DOI: 10.1016/j.cct.2022.106964

Link outs

Free resources

Full Text Sources:

Medical:

https://clinicaltrials.gov/search?term=AREA%5BRefe...

Miscellaneous:

https://assays.cancer.gov/CPTAC-1240

Subscription / membership required

Full Text Sources:

MeSH Terms: Child, Humans, Zeaxanthins, Lutein, Cross-Sectional Studies, Macular Pigment, Cognition, Dietary Supplements, Randomized Controlled Trials as Topic