Selenium and selenoproteins in thermogenic adipocytes.

Briana K Shimada, Ligia M Watanabe, Sydonie Swanson, Pamela Toh, Lucia A Seale

Journal: Archives of biochemistry and biophysics 2022;731():109445

PMID: 36265651

Free Full Text on PubMed Central View on PubMed

Abstract

Selenium (Se) is involved in energy metabolism in the liver, white adipose tissue, and skeletal muscle, and may also play a role in thermogenic adipocytes, i.e. brown and beige adipocytes. Thereby this micronutrient is a key nutritional target to aid in combating obesity and metabolic diseases. In thermogenic adipocytes, particularly in brown adipose tissue (BAT), the selenoprotein type 2 iodothyronine deiodinase (DIO2) is essential for the activation of adaptive thermogenesis. Recent evidence has suggested that additional selenoproteins may also be participating in this process, and a role for Se itself through its metabolic pathways is also envisioned. In this review, we discuss the recognized effects and the knowledge gaps in the involvement of Se metabolism and selenoproteins in the mechanisms of adaptive thermogenesis in thermogenic (brown and beige) adipocytes.

Address: Pacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, HI, USA.; Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.; Pacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, HI, USA. Electronic address: [email protected].

DOI: 10.1016/j.abb.2022.109445

Link outs

Free resources

Full Text Sources:

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0003...

MeSH Terms: Selenium, Thermogenesis, Adipose Tissue, Brown, Adipocytes, Energy Metabolism, Selenoproteins