The effects of conjugated linoleic acid supplementation on liver function enzymes and malondialdehyde in adults: A GRADE-assessed systematic review and dose-response meta-analysis.

Neda Haghighat, Ghazaleh Shimi, Farideh Shiraseb, Ashkan Karbasi, Maryam Nadery, Damoon Ashtary-Larky, Mohammad Zamani, Omid Asbaghi

Journal: Pharmacological research 2022;186():106518

PMID: 36270407

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Previous research reported inconsistent findings regarding the effects of conjugated linoleic acid (CLA) supplementation on liver enzymes. This systematic review and meta-analysis was conducted to summarize data from available randomized clinical trials (RCTs) on the effect of CLA supplementation on alanine aminotransferase (ALT), aspartate aminotransferase (AST) and malondialdehyde (MDA) in adults.

METHODS

Google Scholar, PubMed, Web of Science, Scopus, and the Cochrane databases were investigated to identify relevant articles up to July 2022. The weighted mean differences (WMD) and 95 % confidence intervals (CI) were calculated via a random-effects model to evaluate the effect size. Between studies, heterogeneity was evaluated by the Cochran's Q test and I.

RESULTS

22 RCTs with 26 effect sizes were included. The effect size for ALT (IU/L), AST (IU/L), and MDA (µmol/L) were 19, 19 and 6 respectively. The pooled analysis demonstrated CLA decreases MDA (p = 0.003). However, ALT and AST levels did not change after CLA supplementation compared with control group.

CONCLUSION

CLA supplementation may significantly reduce MDA levels as a marker of oxidative stress. However, supplementing with CLA failed to alter ALT and AST.

Published by Elsevier Ltd.

Address: laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: [email protected].; Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, 1981619573 Tehran, Iran. Electronic address: [email protected].; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: [email protected].; Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: [email protected].; PhD student at Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work Florida International University, United States. Electronic address: [email protected].; Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: [email protected].; Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Cancer Research Center, Shahid Beheshti University of Medical sciences, Tehran, Iran; Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.phrs.2022.106518

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Linoleic Acids, Conjugated, Malondialdehyde, Dietary Supplements, Aspartate Aminotransferases, Liver