Acid-sensing ion channel 1: potential therapeutic target for tumor.

Yinghong Wang, Hong Zhou, Yancai Sun, Yan Huang

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022;155():113835

PMID: 36271585

Free Full Text on Elsevier Science View on PubMed

Abstract

Acidic extracellular pH is a major characteristic of tumor tissue, studies suggest that the local pH value of malignant tumor tissues is between 6.0 and 6.9. Acid-sensing ion channel 1 (ASIC1) is proton-gated cation channel activated by low extracellular pH, recently an increasing number of studies have suggested that ASIC1 is involved in different kinds of tumors, which plays an important role in the occurrence and development of tumors. Therefore, this review will summarize studies involved in ASIC1 on tumors and discuss the effect and mechanism of ASIC1 in numerous related tumors, which will provide new perspectives for tumor therapeutic targets.

Address: Department of Pharmacy, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Pharmacy, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. Electronic address: [email protected].; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China. Electronic address: [email protected].

DOI: 10.1016/j.biopha.2022.113835

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MeSH Terms: Humans, Acid Sensing Ion Channels, Protons, Neoplasms