Ferritin self-assembly, structure, function, and biotechnological applications.

Anatolii E Mikhailov, Alexey V Vlasov, Alexander I Kuklin, Ivan Yu Gushchin, Valentin I Gordeliy, Andrey V Rogachev, Ilya V Manukhov, Tatiana N Murugova, Daria D Kuklina, Vsevolod V Sudarev, Stepan D Osipov, Nikolay A Bondarev, Vladimir N Uversky, Yury L Ryzhykau, Sergey V Bazhenov, Siarhei M Bukhalovich, Sofya M Dolotova

Journal: International journal of biological macromolecules 2022;224():319-343

PMID: 36280176

Full Text on Elsevier Science View on PubMed

Abstract

Ferritin is a vital protein complex responsible for storing iron in almost all living organisms. It plays a crucial role in various metabolic pathways, inflammation processes, stress response, and pathogenesis of cancer and neurodegenerative diseases. In this review we discuss the role of ferritin in diseases, cellular iron regulation, its structural features, and its role in biotechnology. We also show that molecular mechanisms of ferritin self-assembly are key for a number of biotechnological and pharmaceutical applications. The assembly pathways strongly depend on the interface context of ferritin monomers and the stability of its different intermediate oligomers. To date, several schemes of self-assembly kinetics have been proposed. Here, we compare different self-assembly mechanisms and discuss the possibility of self-assembly control by switching between deadlock intermediate states.

Address: Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia.; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia; HSE University, 101000 Moscow, Russia.; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, 141980 Dubna, Russia.; Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States of America.; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, 141980 Dubna, Russia.; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia; HSE University, 101000 Moscow, Russia; Laboratory of Microbiology, Moscow State University of Food Production, Volokolamskoe Highway 11, 125080 Moscow, Russia.; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52425 Jülich, Germany; JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, 52428 Jülich, Germany; Institut de Biologie Structurale Jean-Pierre Ebel, Université Grenoble Alpes-Commissariat à l'Energie Atomique et aux Energies Alternatives-CNRS, F-38027 Grenoble, France.; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, 141980 Dubna, Russia. Electronic address: [email protected].

DOI: 10.1016/j.ijbiomac.2022.10.126

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MeSH Terms: Ferritins, Iron