Multifaceted role of synbiotics as nutraceuticals, therapeutics and carrier for drug delivery.

Aftab Alam, Kamal Dua, Niraj Kumar Jha, Amie Steel, Flavia Zacconi, Gaurav Gupta, Srinivas Nammi, Zeenat Parveen, Faris F Aba Alkhayl, Sulaiman Mohammed Alnasser, Rubiya Khursheed, Leander Corrie, Deep Shikha Sharma, Sachin Kumar Singh, Jon Adams, Sukriti Vishwas, Monica Gulati, Dinesh Kumar Chellappan, Sheetu Wadhwa

Journal: Chemico-biological interactions 2022;368():110223

PMID: 36283466

Full Text on Elsevier Science View on PubMed

Abstract

Synbiotics, are a combination of probiotics and prebiotics. They play an important role in metabolizing different nutritional substrates and thus helps in the maintenance of human health. Any disbalance in the gut microflora, known as dysbiosis, is known to lead to a number of diseased conditions. It can be reverted by the administration of synbiotics. Present review highlights various mechanistic pathways through which synbiotics act as therapeutics. The dual role of synbiotics as nutraceutical and excipient in developing oral formulations are entailed with case studies. The findings entailed that there exist numerous studies on prebiotics as well as probiotics have been carried out to show their effects in several diseases. However, the concept of combining together them for prevention and treatment of various pathological conditions accruing from dysbiosis is relatively new. Synbiotics, however, face challenge of low stability during their sojourn in the GIT, which is generally overcome by various encapsulation techniques. Various studies also showed potential role of synbiotics in drug delivery. However, it is an emerging area and lacks clinical correlation. It is important to focus on clinical trials of formulations wherein synbiotics have been used as therapeutic moiety as well as pharmaceutical carrier for treating various diseases.

Address: School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia.; Pharmacology and Toxicology Department, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia.; Department of Pharmaceutical Chemistry and Pharmacognosy, College of Dentistry and Pharmacy, Buraydah Colleges, Buraydah, Saudi Arabia; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.; CT Institute of Pharmaceutical Sciences, CT University, Jalandhar, India.; School of Science, Western Sydney University, Penrith, NSW, 2751, Australia.; Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.; School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.; Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, Macul, Santiago, 7820436, Chile.; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.; Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No.32-34 Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun, 248007, India.; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW, 2007, Australia.; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia. Electronic address: [email protected].

DOI: 10.1016/j.cbi.2022.110223

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MeSH Terms: Humans, Synbiotics, Prebiotics, Dysbiosis, Excipients, Probiotics