Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics.

Sergey Tsymbal, Ge Li, Nikol Agadzhanian, Yuhao Sun, Jiazhennan Zhang, Marina Dukhinova, Viacheslav Fedorov, Maxim Shevtsov

Journal: Molecules (Basel, Switzerland) 2022;27(20):0

PMID: 36296659

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Abstract

Treatment of drug-resistant forms of cancer requires consideration of their hallmark features, such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways. Malignant cells differ from their normal counterparts in numerous aspects, including copper metabolism. Intracellular copper levels are elevated in various cancer types, and this phenomenon could be employed for the development of novel oncotherapeutic approaches. Copper maintains the cell oxidation levels, regulates the protein activity and metabolism, and is involved in inflammation. Various copper-based compounds, such as nanoparticles or metal-based organic complexes, show specific activity against cancer cells according to preclinical studies. Herein, we summarize the major principles of copper metabolism in cancer cells and its potential in cancer theranostics.

Address: International Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, 197101 Saint Petersburg, Russia.; Cancer Center & Department of Breast and Thyroid Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, 2000 Xiang'an Road East, Xiamen 361101, China.; Xiamen Key Laboratory for Endocrine-Related Cancer Precision Medicine, Xiang'an Hospital of Xiamen University, Xiamen 361101, China.; Guangxi University of Chinese Medicine, Nanning 530200, China.; Day-Care Department, Xinjiang Medical University, Urumqi 830011, China.; Laboratory of Biomedical Nanotechnologies, Institute of Cytology of the Russian Academy of Sciences, 194064 Saint Petersburg, Russia.; Personalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.; Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

DOI: 10.3390/molecules27207066

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MeSH Terms: Humans, Copper, Precision Medicine, Nanoparticles, Neoplasms, Coordination Complexes