Precise oral delivery systems for probiotics: A review.

Ya Luo, Cristabelle De Souza, Mythili Ramachandran, Shaolei Wang, Huaxi Yi, Zhao Ma, Lanwei Zhang, Kai Lin

Journal: Journal of controlled release : official journal of the Controlled Release Society 2022;352():371-384

PMID: 36309096

Full Text on Elsevier Science View on PubMed

Abstract

Probiotics have several health benefits to the host. However, low pH in the stomach, various digestive enzymes and bile salts in the intestine threaten their viability and function. Thus, probiotics need to be protected during gastric transit to address challenges associated with low viability and impaired function. At present, probiotic delivery systems with different trigger mechanisms have been constructed to successfully introduce numerous high-viability probiotics to the intestine. On this basis, the application of non-targeted/targeted probiotic delivery systems in different gut microenvironment and the adjuvant therapeutic effect of probiotic delivery systems on other disease were discussed in detail. It is important to also note that most of the current studies in this area focused on non-targeted probiotic delivery systems. Moreover, changes in intestinal microenvironment under disease state and discontinuous distribution of disease site limit their development. Thus, emphasis were made on the optimization of non-targeted probiotic delivery systems and the necessity of designing more precisely targeted ones.

Address: College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266003, China.; Department of Stem Cell Research and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.; Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA.; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266003, China. Electronic address: [email protected].; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266003, China. Electronic address: [email protected].

DOI: 10.1016/j.jconrel.2022.10.030

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MeSH Terms: Probiotics, Bile Acids and Salts