Insights on the potential oncogenic impact of long non-coding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 in different cancer types; integrating pathway(s) and clinical outcome(s) association.

Nada M El-Sheikh, Ahmed I Abulsoud, Eman F Wasfey, Nadia M Hamdy

Journal: Pathology, research and practice 2022;240():154183

PMID: 36327824

Full Text on Elsevier Science View on PubMed

Abstract

Long non-coding RNAs (lncRNAs) are becoming more prevalent in the cancer field arena, with functional roles in both oncogenic and onco-suppressive pathways. Despite their widespread aberrant expression in a range of human malignancies, the biological activities of the ncRNAs majority are unknown. All showed the involvement of the lncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1). Since NNT-AS1 influences cellular proliferation, invasion, migration, apoptosis, and metastasis, this lncRNA appears to be linked to deregulating the normal cellular processes driving malignancy. This was observed in breast cancer (BC), gastric cancer (GC), colorectal cancer (CRC), epithelial ovarian cancer (EOC), and hepatocellular carcinoma (HCC). The current narrative non-systematic review will discuss "the significance of lncRNAs in cancer", as well as "lncRNAs future potential application(s) as diagnostic or predictive biomarkers", therefore, comprising an opportunity as treatment target(s). The review will have a special emphasis on lncRNA NNT-AS1.

Address: Biochemistry Department, Faculty of Pharmacy, Heliopolis University, El Salam City, Cairo 11785, Egypt.; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, El Salam City, Cairo 11785, Egypt; Biochemistry Department, Faculty of Pharmacy (Boy's branch), Al-Azhar University, Nasr City, Cairo 11884, Egypt.; Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.; Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt. Electronic address: [email protected].

DOI: 10.1016/j.prp.2022.154183

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MeSH Terms: Humans, RNA, Long Noncoding, RNA, Antisense, NADP Transhydrogenases, Gene Expression Regulation, Neoplastic, Carcinoma, Hepatocellular, Liver Neoplasms, Cell Proliferation, Carcinogenesis, Cell Line, Tumor, Cell Movement, MicroRNAs