Boron-containing compounds on neurons: Actions and potential applications for treating neurodegenerative diseases.

Mónica Barrón-González, Alexia V Montes-Aparicio, M Emilio Cuevas-Galindo, Sandra Orozco-Suárez, Rafael Barrientos, Alberto Alatorre, Enrique Querejeta, José G Trujillo-Ferrara, Eunice D Farfán-García, Marvin A Soriano-Ursúa

Journal: Journal of inorganic biochemistry 2022;238():112027

PMID: 36345068

Full Text on Elsevier Science View on PubMed

Abstract

Boron-containing compounds (BCC) exert effects on neurons. After the expanding of both the identification and synthesis of new BCC, novel effects in living systems have been reported, many of these involving neuronal action. In this review, the actions of BCC on neurons are described; the effects have been inferred by boron deprivation or addition. Also, the effects can be related to those mediated by interaction on ionic channels, G-protein coupled receptors, or other receptors exerting modification on neuronal behavior. Additionally, BCC have exhibited effects by the modulation of inflammation or oxidative processes. BCC are expanding as drugs. Deprivation of boron sources from the diet shows the role of some natural BCC. However, the observations of several new synthesized compounds suggest their ability to act with attractive potency, efficacy, and long-term action on neuronal receptors or processes related with the origin and evolution of neurodegenerative processes. The details of BCC-target interactions are currently being elucidated in progress, as those observed from BCC-protein crystal complexes. Taking all of the above into account, the expansion is presumably near to having studies on the application of BCC as drugs on specific targets for treating neurodegenerative diseases.

Address: Academia de Fisiología, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Alc. Miguel Hidalgo, 11340 Mexico City, Mexico; Departamento de Bioquímica, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Alc. Miguel Hidalgo, 11340 Mexico City, Mexico.; Academia de Fisiología, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Alc. Miguel Hidalgo, 11340 Mexico City, Mexico; Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, 06720 Mexico City, Mexico.; Departamento de Bioquímica, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Alc. Miguel Hidalgo, 11340 Mexico City, Mexico.; Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, 06720 Mexico City, Mexico.; Academia de Fisiología, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Alc. Miguel Hidalgo, 11340 Mexico City, Mexico.; Departamento de Bioquímica, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Alc. Miguel Hidalgo, 11340 Mexico City, Mexico. Electronic address: [email protected].; Academia de Fisiología, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Alc. Miguel Hidalgo, 11340 Mexico City, Mexico. Electronic address: [email protected].

DOI: 10.1016/j.jinorgbio.2022.112027

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MeSH Terms: Humans, Neurodegenerative Diseases, Boron, Boron Compounds, Neurons, Inflammation