Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus .

Gaber El-Saber Batiha, Nosheen Akhtar, Abdulrahman A Alsayegh, Wafaa Fouzi Abusudah, Najlaa Hamed Almohmadi, Hazem M Shaheen, Thakur Gurjeet Singh, Michel De Waard

Journal: Molecules (Basel, Switzerland) 2022;27(21):7340

PMID: 36364163

Abstract

Plants are a promising source of bioactive compounds that can be used to tackle many emerging diseases both infectious and non-infectious. Among different plants, is a very large genus and exhibits a diverse array of bioactive agents with remarkable pharmacological properties against different diseases. , a herb found all over the world, contains approximately more than 1200 species of the Fabaceae family. In the present review, we have collected detailed information on biochemical as well as pharmacological properties. The data were retrieved using different databases, such as Elsevier, PubMed, Science Direct, Google Scholar, and Scopus, and an extensive literature survey was carried out. Studies have shown that possesses several secondary metabolites, including amines, cyanogenic glycosides, flavonoids, alkaloids, seed oils, cyclitols, fluoroacetate, gums, non-protein amino acids, diterpenes, fatty acids, terpenes, hydrolyzable tannins, and condensed tannins. These compounds exhibit a wide range of pharmaceutical applications such as anti-inflammatory, antioxidant, antidiarrheal, antidiabetic, anticancer, antiviral, liver protective effects, and so on. Thus, the literature shows the tremendous phytochemical impact of the genus in medicine. Overall, we recommend that more research should be conducted on the medicinal value and isolation and purification of the effective therapeutic agents from species for the treatment of various ailments.

Address: Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.; Department of Biological Sciences, National University of Medical Sciences, Islamabad 46000, Pakistan.; Clinical Nutrition Department, Applied Medical Sciences College, Jazan University, Jazan 82817, Saudi Arabia.; Clinical Nutrition Department, College of Applied Medical Sciences, Umm Al-Qura University, Makkah 24381, Saudi Arabia.; Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.; Smartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egrève, France.; L'institut du Thorax, INSERM, CNRS, Université de Nantes, 44007 Nantes, France.; LabEx «Ion Channels, Science & Therapeutics», Université de Nice Sophia-Antipolis, 06560 Valbonne, France.
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