Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review.

Roshina Rabail, Allah Rakha, Marek Kieliszek, Nehal Umar, Masood Sadiq Butt, Abdo Hassoun, Rana Muhammad Aadil

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022;156():113945

PMID: 36411631

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Abstract

Chronic inflammation plays an imperative role in the onset and progression of chronic diseases including diabetes, hypertension, cancer, allergies, and asthma. Diet can modulate different stages of inflammation since it is a rich source of antioxidants and bioactive compounds. Flavonoids are bioactive compounds abundantly found in various food groups such as vegetables, fruits, nuts, cereals, and beverages. Recent work on flavonoids has unveiled their potential to regulate or inhibit inflammation. This is attributed to their anti-inflammatory, anti-oxidative, and immune-modulatory properties, making flavonoids an invaluable component in nutraceutical, pharmaceutical, and medicinal applications. However, information related to their anti-inflammatory mechanism is still not well understood. The current review is an attempt to elaborate chemical structure, dietary sources, and anti-inflammatory properties of flavonoids against allergic diseases.

Address: National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan.; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan. Electronic address: [email protected].; Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland. Electronic address: [email protected].; Univ. Littoral Côte d'Opale, UMRt 1158 BioEcoAgro, USC ANSES, INRAe, Univ. Artois, Univ. Lille, Univ. Picardie Jules Verne, Univ. Liège, Junia, F-62200, Boulogne-sur-Mer, France; Sustainable AgriFoodtech Innovation & Research (SAFIR), 62000 Arras, France.; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan. Electronic address: [email protected].

DOI: 10.1016/j.biopha.2022.113945

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MeSH Terms: Anti-Allergic Agents, Polyphenols, Anti-Inflammatory Agents, Flavonoids, Vegetables, Hypersensitivity, Inflammation