Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.

Jane Margaret Anderson, Lauren Moy, Ronald L Moy

Journal: Dermatologic clinics 2022;41(1):231-238

PMID: 36410981

Full Text on Elsevier Science View on PubMed

Abstract

Chemoprophylaxis against nonmelanoma skin cancer (NMSC) should be considered in high-risk populations such as those with certain genetic disorders, immunosuppressive states, chronic radiation, excessive UV exposure, or extensive personal or family history of NMSC. The methods for chemoprevention have progressed beyond traditional sunscreen into more effective strategies including DNA repair enzymes, nicotinamide, systemic retinoids, and nonsteroidal anti-inflammatory drugs. Other therapies are still being investigated and include treatments that target premalignant lesions, capecitabine, hedgehog inhibitors, difluoromethylornithine, metformin, and nutritional factors.

Address: Research Department, Moy-Fincher-Chipps Facial Plastics & Dermatology, 421 North Rodeo Drive #T-7, Beverly Hills, CA 90210, USA; The University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.; Research Department, Moy-Fincher-Chipps Facial Plastics & Dermatology, 421 North Rodeo Drive #T-7, Beverly Hills, CA 90210, USA.; Research Department, Moy-Fincher-Chipps Facial Plastics & Dermatology, 421 North Rodeo Drive #T-7, Beverly Hills, CA 90210, USA. Electronic address: [email protected].

DOI: 10.1016/j.det.2022.07.020

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MeSH Terms: Humans, Hedgehog Proteins, Skin Neoplasms, Chemoprevention, Retinoids, Niacinamide