Role of IL-22 in intestinal microenvironment and potential targeted therapy through diet.

Peiying Wang, Wing Keung Chan, Jiming Wang, Zhouxin Yang, Youwei Wang

Journal: Immunologic research 2023;71(2):121-129

PMID: 36173554

Abstract

IL-22 is a type 2 receptor cytokine in IL-10 family. IL-22 is usually secreted by innate and adaptive immune cells and takes its effects on non-hematopoietic cells. Through activate STAT3 pathway, IL-22 plays an important role in infection clearance and tissue regeneration, which is critical for barrier integrate and homeostasis. Abnormal activation of IL-22 signal was observed in inflammation diseases, autoimmune diseases, and cancers. We review the recent discoveries about the mechanism and regulation of IL-22 signal pathway from the perspective of intestinal micro-environment. Diet-based IL-22 target therapeutic strategies and their potential clinical significance will also be discussed.

Address: Institute of Medical Engineering & Translational Medicine, Tianjin University, 92 Weijin Road, Tianjin, 300072, China.; Department of Internal Medicine, Division of Hematology, The Ohio State University, 400 W. 12th Ave, Columbus, OH, 43210, USA.; Tianjin Economic-Technological Development Area (TEDA) Hospital, 65 3rd Ave, Tianjin, 300451, China.; Department of Critical Care Medicine, Zhejiang Hospital, 1229 Gudun Road, Hangzhou, 310030, China. [email protected].; Institute of Medical Engineering & Translational Medicine, Tianjin University, 92 Weijin Road, Tianjin, 300072, China. [email protected].

DOI: 10.1007/s12026-022-09325-5

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https://dx.doi.org/10.1007/s12026-022-09325-5

MeSH Terms: Humans, Interleukins, Intestines, Cytokines, Diet, Immunity, Innate, Inflammation, Interleukin-22