Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis.

Xi Luo, Xiao-Ke Wu, Wang-Yu Cai, Wei Wu, Jianyuan Song, Ning-Ning Xie, Cuicui Duan, Jian Xu

Journal: Journal of ovarian research 2022;15(1):109

PMID: 36180908

Free Full Text on BioMed Central View on PubMed

Abstract

OBJECTIVE

This review aimed to investigate the metabolic profile of women with premature ovarian insufficiency (POI) compared relative to women with normal ovarian functioning.

METHODS

A systematic search of PubMed, EMBASE, and the Web of Science for observational studies published up until the 6 of July 2021 that compared the metabolic profile of POI women with a healthy control group were assessed. Mean differences (MD) and 95% confidence interval (CI) were pooled using the fixed or random effect models.

RESULTS

A total of 21 studies involving 1573 women with POI and 1762 control women were included. POI patients presented significantly higher waist circumference, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, and fasting glucose. Additionally, POI patients had marginally higher insulin level. However, the differences in systolic, and diastolic blood pressure were non-significant relative to the control group.

CONCLUSIONS

POI is associated with alterations in certain metabolic parameters compared to control women. This finding highlights the importance of early screening and the lifelong management of metabolic health for women with POI.

Address: Fourth Affiliated Hospital, Zhejiang University School of Medicine, No. 1 Shang Cheng Avenue, Yiwu, 322000, Zhejiang, China.; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.; Center of Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.; Heilongjiang Province Hospital, Harbin, China.; Fourth Affiliated Hospital, Zhejiang University School of Medicine, No. 1 Shang Cheng Avenue, Yiwu, 322000, Zhejiang, China. [email protected].; Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China. [email protected].

DOI: 10.1186/s13048-022-01041-w

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MeSH Terms: Cholesterol, Female, Glucose, Humans, Insulins, Lipoproteins, Lipoproteins, HDL, Menopause, Premature, Primary Ovarian Insufficiency, Triglycerides