Effect of caffeine on mitochondrial biogenesis in the skeletal muscle - A narrative review.

Craig Pickering, André K Yamada, Gustavo D Pimentel, André V Cordeiro, Vagner R R Silva

Journal: Clinical nutrition ESPEN 2022;51():1-6

PMID: 36184193

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Abstract

Caffeine is one of the most widely used substances as recreational drug for performance-enhancement in sport, underpinned by a strong evidence base. Although the effects of caffeine are widely investigated within the scope of performance physiology, the molecular effects of caffeine within skeletal muscle remain unclear. Evidence from in vitro and in vivo models suggest that caffeine regulates the glucose metabolism in the skeletal muscle. Moreover, caffeine seems to stimulate CaMKII, PPARδ/β, AMPK and PGC1α, classical markers of exercise-adaptations, including mitochondrial biogenesis and mitochondrial content. This review summarizes evidence to suggest caffeine-effects within skeletal muscle fibers, focusing on the putative role of caffeine on mitochondrial biogenesis to explore whether caffeine supplementation might be a strategy to enhance mitochondrial biogenesis.

Address: Faculty of Health Sciences, Methodist University of Piracicaba (UNIMEP), Brazil.; Faculty of Nutrition, Federal University of Goiás, Brazil.; Institute of Coaching and Performance, School of Sport and Wellbeing, University of Central Lancashire, Fylde Road, Preston, PR1 2HE, UK.; Faculty of Health Sciences, University Anhanguera. São Paulo, SP, Brazil.; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: [email protected].

DOI: 10.1016/j.clnesp.2022.09.001

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MeSH Terms: AMP-Activated Protein Kinases, Caffeine, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Glucose, Humans, Illicit Drugs, Muscle, Skeletal, Organelle Biogenesis, PPAR delta, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha