Roles of activator protein-2 gamma in breast cancer: A narrative review (SANRA).

Yifei Zhang, Asal Aa Mostafa, Natthida Sriboonvorakul, Jiamiao Hu

Journal: Medicine 2022;101(38):e30587

PMID: 36197225

Free Full Text on PubMed Central View on PubMed

Abstract

Activator protein-2 gamma (AP-2γ) is a crucial transcription factor involved in breast cancer development. Abnormal expression and activity of AP-2γ have also been identified as important markers of malignancy. In the last decade, the importance of AP-2γ in breast cancer progression has been widely studied. In this review, we summarize the current knowledge on the regulatory roles of AP-2γ in breast cancer oncogenesis and progression and its potential as a diagnostic biomarker and drug target in breast cancer treatment.

Address: Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, Fujian, China.; Food Technology Research Institute, Agriculture Research Center, Egypt.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Faculty of Health Sciences, University of Macau, Macau, China.

DOI: 10.1097/MD.0000000000030587

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/breastcancer.html

Subscription / membership required

Full Text Sources:

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linko...

MeSH Terms: Breast, Breast Neoplasms, Female, Gene Expression Regulation, Humans, Transcription Factor AP-2, Transcription Factors