N-glycan branching enzymes involved in cancer, Alzheimer's disease and COPD and future perspectives.

Naoyuki Taniguchi, Yuki Ohkawa, Kento Maeda, Noriko Kanto, Emma Lee Johnson, Yoichiro Harada

Journal: Biochemical and biophysical research communications 2022;633():68-71

PMID: 36344167

Full Text on Elsevier Science View on PubMed

Abstract

Over the past 3 decades, our group has been involved in studies related to the biosynthesis of N-glycan branching and related glycosyltransferases and have purified most of these Golgi-derived enzymes to homogeneity using classical purification methods and cloned the cDNA of GnT-III, IV, V, VI and Fut8 except GnT-IX(Vb) which was obtained by homology cloning. Based primarily on our data, we briefly summarize the significance of three major enzymes and discuss perspectives for future studies on the occasion of Ernesto's 90th birthday celebration.

Address: Department of Glyco-Oncology and Medical Biochemistry, Research Center, Osaka International Cancer Institute, Osaka, Japan. Electronic address: [email protected].; Department of Glyco-Oncology and Medical Biochemistry, Research Center, Osaka International Cancer Institute, Osaka, Japan.

DOI: 10.1016/j.bbrc.2022.09.027

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MeSH Terms: Humans, N-Acetylglucosaminyltransferases, Alzheimer Disease, 1,4-alpha-Glucan Branching Enzyme, Polysaccharides, Neoplasms, Pulmonary Disease, Chronic Obstructive