Molecular insights and therapeutic implications of nanoengineered dietary polyphenols for targeting lung carcinoma: part I.

Sabya Sachi Das, Srushti Tambe, Priya Ranjan Prasad Verma, Purnima Amin, Neeru Singh, Sandeep Kumar Singh, Piyush Kumar Gupta

Journal: Nanomedicine (London, England) 2023;17(23):1779-1798

PMID: 36636930

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Abstract

Lung cancer is the second leading cause of cancer-related mortality globally, and non-small-cell lung cancer accounts for most lung cancer cases. Nanotechnology-based drug-delivery systems have exhibited immense potential in lung cancer therapy due to their fascinating physicochemical characteristics, stability, bioavailability, prolonged and targeted delivery, gastrointestinal absorption and therapeutic efficiency of their numerous chemotherapeutic agents. However, traditional chemotherapeutics have systemic toxicity issues; therefore, dietary polyphenols might potentially replace them in lung cancer treatment. Polyphenol-based targeted nanotherapeutics have demonstrated interaction with a multitude of protein targets and cellular signaling pathways that affect major cellular processes. This review summarizes the various molecular mechanisms and targeted therapeutic potentials of nanoengineered dietary polyphenols in the effective management of lung cancer.

Address: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.; School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun, Uttarakhand, 248009, India.; Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India.; Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.; Department of Biomedical Laboratory Technology, University Polytechnic, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.; Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, 201310, India.; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, 248002, India.; Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia.

DOI: 10.2217/nnm-2022-0133

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MeSH Terms: Humans, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Polyphenols, Lung, Carcinoma