Sorting nexins as a promising therapeutic target for cardiovascular disorders: An updated overview.

Fatemeh Yarmohammadi, A Wallace Hayes, Gholamreza Karimi

Journal: Experimental cell research 2022;419(1):113304

PMID: 35931142

Full Text on Elsevier Science View on PubMed

Abstract

Sorting nexins (SNXs) are involved in sorting the protein cargo within the endolysosomal system. Recently, several studies have shown the role of SNXs in cardiovascular pathology. SNXs exert both physiologic and pathologic functions in the cardiovascular system by regulating protein sorting and trafficking, maintaining protein homeostasis, and participating in multiple signaling pathways. SNX deficiency results in blood pressure response to dopamine 5 receptor [D5R] stimulation. SNX knockout protected against atherosclerosis lesions by suppressing foam cell formation. Moreover, SNXs can act as endogenous anti-arrhythmic agents via maintenance of calcium homeostasis. Overexpression SNXs also can reduce cardiac fibrosis in atrial fibrillation. The SNX-STAT3 interaction in cardiac cells promoted heart failure. SNXs may have the potential to act as a pharmacological target against specific cardiovascular diseases.

Address: Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, FL,, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].

DOI: 10.1016/j.yexcr.2022.113304

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MeSH Terms: Cardiovascular Diseases, Cardiovascular System, Endosomes, Humans, Protein Transport, Sorting Nexins