Advances in screening of thalassaemia.

Jie Gao, Wenjun Liu

Journal: Clinica chimica acta; international journal of clinical chemistry 2022;534():176-184

PMID: 35932850

Full Text on Elsevier Science View on PubMed

Abstract

Thalassaemia is a common hereditary haemolytic anaemia. Mild cases of this disease may be asymptomatic, while patients with severe thalassaemias require high-dose blood transfusions and regular iron removal to maintain life or haematopoietic stem cell transplantation to be cured, imposing an enormous familial and social burden. Therefore, early, timely, and accurate screening of patients is of great importance. In recent years, with the continuous development of thalassaemia screening technologies, the accuracy of thalassaemia screening has also improved significantly. This article reviews the current research on thalassaemia screening.

Address: Department of Pediatrics, Children Hematological Oncology and Birth Defects Laboratory, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Department of Pediatrics, Southwest Medical University, Luzhou, Sichuan 646000, China.; Department of Pediatrics, Children Hematological Oncology and Birth Defects Laboratory, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Department of Pediatrics, Southwest Medical University, Luzhou, Sichuan 646000, China; Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China. Electronic address: [email protected].

DOI: 10.1016/j.cca.2022.08.001

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MeSH Terms: Blood Transfusion, Humans, Mass Screening, Thalassemia, beta-Thalassemia