Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights.

Bowen Li, Bo Yang, Xiaoming Liu, Jianxin Zhao, R Paul Ross, Catherine Stanton, Hao Zhang, Wei Chen

Journal: Cellular and molecular life sciences : CMLS 2022;79(9):470

PMID: 35932328

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Abstract

Research on the influence of gut microbiota on systemic inflammatory arthritis has exploded in the past decade. Gut microbiota changes may be a crucial regulatory component in systemic inflammatory arthritis. As a result of advancements in the field, microbiota-assisted therapy has evolved, but this discipline is still in its infancy. Consequently, we review the limitations of current systemic inflammatory arthritis treatment, analyze the connection between the microbiota and arthritis, and summarize the research progress of microbiota regulating systemic inflammatory arthritis and the further development aspects of microbiota-assisted therapy. Finally, the partial mechanisms of microbiota-assisted therapy of systemic inflammatory arthritis are being discussed. In general, this review summarizes the current progress, challenges, and prospects of microbiota-assisted therapy for systemic inflammatory arthritis and points out the direction for the development of microbiota-assisted therapy in the future.

Address: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China. [email protected].; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China. [email protected].; International Joint Research Center for Probiotics and Gut Health, Jiangnan University, Wuxi, Jiangsu, China. [email protected].; International Joint Research Center for Probiotics and Gut Health, Jiangnan University, Wuxi, Jiangsu, China.; International Joint Research Center for Probiotics and Gut Health, Jiangnan University, Wuxi, Jiangsu, China. [email protected].; APC Microbiome Ireland, University College Cork, Cork, Ireland. [email protected].; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, China.; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China. [email protected].; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China. [email protected].; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, China. [email protected].; Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, China. [email protected].

DOI: 10.1007/s00018-022-04498-6