Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis.

Aung Myint Tun, Kyaw Zin Thein, Zin War Myint, Thein Hlaing Oo

Journal: Cardiovascular & hematological agents in medicinal chemistry 2018;15(1):17-22

PMID: 28164751

Abstract

BACKGROUND

Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations.

CONCLUSION

Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.

Address: The Brooklyn Hospital Center, Brooklyn, New York, United States.; Texas Tech University Health Sciences Center, Lubbock, TX, United States.; University of Kentucky, Lexington, KY, United States.; The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, United States.

DOI: 10.2174/1871525715666170203114632

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MeSH Terms: Anemia, Pernicious, Autoantibodies, Gastritis, Atrophic, Humans, Vitamin B 12, Vitamin B 12 Deficiency