Human variants of O6-alkylguanine-DNA alkyltransferase.

Anthony E Pegg, Qingming Fang, Natalia A Loktionova

Journal: DNA repair 2007;6(8):1071-8

PMID: 17482892

Free Full Text on PubMed Central View on PubMed

Abstract

This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O(6)-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy.

Address: Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA. [email protected]

DOI: 10.1016/j.dnarep.2007.03.012