Integration of nutritional and stress signaling pathways by Maf1.

Ian M Willis, Robyn D Moir

Journal: Trends in biochemical sciences 2007;32(2):51-3

PMID: 17174096

Full Text on Elsevier Science View on PubMed

Abstract

Repression of RNA polymerase III transcription under many conditions requires Maf1, a yeast protein with close sequence homologs in all eukaryotes. Three recent studies have identified key aspects of Maf1 regulation, which suggest that Maf1 integrates the responses from convergent nutritional and stress signaling pathways. These new findings indicate that the opposing actions of protein kinase A and protein phosphatase 2A alter the phosphorylation state of Maf1 and thereby regulate its localization and repressing activity.

Address: Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. [email protected]

DOI: 10.1016/j.tibs.2006.12.001

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MeSH Terms: Cyclic AMP-Dependent Protein Kinases, Nuclear Localization Signals, Oxidative Stress, Phosphoprotein Phosphatases, Protein Phosphatase 2, RNA Polymerase III, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction, Transcription Factors, Transcription, Genetic