The use of substrate engineering in biohydroxylation.

Anna de Raadt, Herfried Griengl

Journal: Current opinion in biotechnology 2003;13(6):537-42

PMID: 12482511

Full Text on Elsevier Science View on PubMed

Abstract

In the biohydroxylation of nonactivated carbon atoms, substrate engineering has been found to be a very useful and simple means to influence substrate acceptance and the regioselectivity and stereoselectivity of this transformation. Recently, this methodology has been applied to the hydroxylation of a large number of compounds including cycloalkane carboxylic acids, ketones, amines, amides and alcohols.

Address: Institute of Organic Chemistry, Technical University Graz, Stremayrgasse 16, A-8010, Graz, Austria.

DOI: 10.1016/s0958-1669(02)00358-0

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MeSH Terms: Bacteria, Catalysis, Chemistry, Organic, Fungi, Hydroxylation, Lipoxygenase, Mixed Function Oxygenases, Protein Engineering, Stereoisomerism, Substrate Specificity