Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives.

Yan Shi, Dun Si, Donghong Chen, Xinfeng Zhang, Zhigang Han, Qiang Yu, Jingjing Liu, Jinping Si

Journal: Food chemistry 2023;408():135183

PMID: 36566543

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Abstract

Diabetes mellitus (DM) is one of the most serious health problems worldwide. Species in the genus Polygonatum are traditional food and medicinal plants, which play an important role in controlling blood glucose. In this reveiw, we systematically summarized the traditional and modern applications of the genus Polygonatum in DM, focused on the material bases of polysaccharides, flavonoids and saponins. We highlighted their mechanisms of action in preventing obese diabetes, improving insulin resistance, promoting insulin secretion, regulating intestinal microecology, inhibiting advanced glycation end products (AGEs) accumulation, suppressing carbohydrate digestion and obsorption and modulating gluconeogenesis. Based on the safety and efficacy of this 'medicinal food' and its utility in the prevention and treatment of diabetes, we proposed a research and development program that includs diet design (supplementary food), medical nutrition therapy and new drugs, which could provide new pathways for the use of natural plants in prevention and treatment of DM.

Address: State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China. Electronic address: [email protected].; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China. Electronic address: [email protected].; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China.; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China. Electronic address: [email protected].; State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, China.; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China. Electronic address: [email protected].; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China. Electronic address: [email protected].

DOI: 10.1016/j.foodchem.2022.135183

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https://linkinghub.elsevier.com/retrieve/pii/S0308...

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https://medlineplus.gov/diabetes.html

MeSH Terms: Polygonatum, Hypoglycemic Agents, Diabetes Mellitus, Plants, Medicinal, Blood Glucose