Organelle Communication: Joined in Sickness and in Health.

Roberto Bravo-Sagua, Camila Lopez-Crisosto, Alfredo Criollo, Reiko Inagi, Sergio Lavandero

Journal: Physiology (Bethesda, Md.) 2023;38(3):0

PMID: 36856309

Abstract

Organelles are membrane-lined structures that compartmentalize subcellular biochemical functions. Therefore, interorganelle communication is crucial for cellular responses that require the coordination of such functions. Multiple principles govern interorganelle interactions, which arise from the complex nature of organelles: position, multilingualism, continuity, heterogeneity, proximity, and bidirectionality, among others. Given their importance, alterations in organelle communication have been linked to many diseases. Among the different types of contacts, endoplasmic reticulum mitochondria interactions are the best known; however, mounting evidence indicates that other organelles also have something to say in the pathophysiological conversation.

Address: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Pharmaceutical and Chemical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.; Laboratory of Obesity and Metabolism (OMEGA), Institute of Nutrition and Food Technology (INTA), Universidad de Chile, Santiago, Chile.; Interuniversity Center for Healthy Aging (CIES), Consortium of Universities of the State of Chile (CUECH), Santiago, Chile.; Cellular and Molecular Biology Laboratory, Institute in Dentistry Sciences, Dentistry Faculty, Universidad de Chile, Santiago, Chile.; Division of Chronic Kidney Disease Pathophysiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

DOI: 10.1152/physiol.00024.2022

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MeSH Terms: Humans, Mitochondria, Endoplasmic Reticulum, Organelles