Effect of metabolic reprogramming on the immune microenvironment in gastric cancer.

Zhiyuan Ma, Biguang Tuo, Xuemei Liu, Zhengye Shang, Enqin Wu, Xingzhao Chen, Taolang Li

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024;170():116030

PMID: 38128177

Free Full Text on Elsevier Science View on PubMed

Abstract

Gastric cancer (GC) is a malignant tumor of the gastrointestinal tract with a high mortality rate worldwide, a low early detection rate and a poor prognosis. The rise of metabolomics has facilitated the early detection and treatment of GC. Metabolism in the GC tumor microenvironment (TME) mainly includes glucose metabolism, lipid metabolism and amino acid metabolism, which provide energy and nutrients for GC cell proliferation and migration. Abnormal tumor metabolism can influence tumor progression by regulating the functions of immune cells and immune molecules in the TME, thereby contributing to tumor immune escape. Thus, in this review, we summarize the impact of metabolism on the TME during GC progression. We also propose novel strategies to modulate antitumor immune responses by targeting metabolism.

Address: Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.; Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Dalian Road 149, Zunyi 563000, China. Electronic address: [email protected].; Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China. Electronic address: [email protected].

DOI: 10.1016/j.biopha.2023.116030