MXene-Based Functional Platforms for Tumor Therapy.

Fan Gao, Chun Xue, Tian Zhang, Lu Zhang, Guo-Yin Zhu, Changjin Ou, Yi-Zhou Zhang, Xiaochen Dong

Journal: Advanced materials (Deerfield Beach, Fla.) 2023;35(51):e2302559

PMID: 37142810

Abstract

Recently, 2D transition metal carbide, nitride, and carbonitrides (MXenes) materials stand out in the field of tumor therapy, particularly in the construction of functional platforms for optimal antitumor therapy due to their high specific surface area, tunable performance, strong absorption of near-infrared light as well as preferable surface plasmon resonance effect. In this review, the progress of MXene-mediated antitumor therapy is summarized after appropriate modifications or integration procedures. The enhanced antitumor treatments directly performed by MXenes, the significant improving effect of MXenes on different antitumor therapies, as well as the MXene-mediated imaging-guided antitumor strategies are discussed in detail. Moreover, the existing challenges and future development directions of MXenes in tumor therapy are presented.

Address: Institute of Advanced Materials and Flexible Electronics (IAMFE), School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing, 210044, China.; Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, China.; National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, China.

DOI: 10.1002/adma.202302559

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https://doi.org/10.1002/adma.202302559

MeSH Terms: Humans, Infrared Rays, Nitrites, Surface Plasmon Resonance, Neoplasms