A novel orthodontic adhesive containing zinc-doped phosphate-based glass for preventing white spot lesions.

Min-Ji Kim, Ji-Young Seo, Il-Jun Jung, Utkarsh Mangal, Hee-Jin Kim, Kee-Joon Lee, Myung-Jin Lee, Jae-Sung Kwon, Sung-Hwan Choi

Journal: Journal of dentistry 2023;137():104689

PMID: 37666468

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVES

This study aimed at demonstrating the remineralization effect of the enamel around the brackets to aid reduction in white spot lesions (WSLs) with use of zinc-doped phosphate-based glass (Zn-PBG) containing orthodontic adhesives.

METHODS

Zn-PBG powder was synthesized, and particle morphology, size, and density were evaluated. Orthodontic adhesives with increasing loading percentage of Zn-PBG powder were prepared: ZnPG3 (3 wt.%), ZnPG6 (6 wt.%), and ZnPG9 (9 wt.%). Brackets were bonded on the etched enamel surface and stored in distilled water (DW) for 1 h. Following, Shear bond strength (SBS) along with adhesive remnant index were analyzed. The release of calcium (Ca), phosphorus (P), and zinc (Zn) from adhesive specimens in DW was evaluated after 7, 15 and 30 days of immersion. The remineralization effect was confirmed by microhardness and surface morphology analysis with scanning electron microscopy.

RESULTS

The SBS value was observed between 20 and 22 MPa on enamel surface. The concentration of Ca, P and Zn released in DW increased with loading percentage of Zn-PBG. The microhardness increased in the experimental groups after immersion in artificial saliva for 7 days. Apatite-like crystal formation was observed after 30 days in the ZnPG 9 group.

CONCLUSIONS

The orthodontic adhesive containing Zn-PBG with an optimal SBS performance has an enamel remineralization effect, and therefore can aid in prevention of WSLs.

CLINICAL SIGNIFICANCE

The orthodontic adhesive containing Zn-PBG is clinically advantageous as it can promote remineralization and resist the formation of WSLs that may occur during orthodontic therapy.

Address: Division in Anatomy and Developmental Biology, Department of Oral Biology, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea; Department of Orthodontics and Institute of Craniofacial Deformity, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea; BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea.; Department of Orthodontics and Institute of Craniofacial Deformity, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea.; Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea.; Division in Anatomy and Developmental Biology, Department of Oral Biology, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea; BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea.; Department of Dental Hygiene, Division of Health Science, Baekseok University, Cheonan, Republic of Korea. Electronic address: [email protected].; BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea; Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea. Electronic address: [email protected].; Department of Orthodontics and Institute of Craniofacial Deformity, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.jdent.2023.104689

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MeSH Terms: Humans, Dental Cements, Powders, Phosphates, Calcium, Dental Caries