A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury.

Kun Liu, Dongfeng Lan, Chunyang Li, Songpo Liu, Xiaofang Dai, Tao Song, Xianyao Wang, Qinghong Kong, Zhixu He, Jun Tan, Jidong Zhang

Journal: Apoptosis : an international journal on programmed cell death 2023;28(3-4):313-325

PMID: 36652128

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Abstract

Apoptosis repressor with caspase recruitment domain (ARC) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. ARC is special for its N-terminal caspase recruitment domain and caspase recruitment domain. Due to the powerful inhibition of apoptosis, ARC is mainly reported to act as a cardioprotective factor during ischaemia‒reperfusion (I/R) injury, preventing cardiomyocytes from being devastated by various catastrophes, including oxidative stress, calcium overload, and mitochondrial dysfunction in the circulatory system. However, recent studies have found that ARC also plays a potential regulatory role in tumorigenesis especially in colorectal cancer and renal cell carcinomas, through multiple apoptosis-associated pathways, which remains to be explored in further studies. Therefore, ARC regulates the body and maintains the balance of physiological activities with its interesting duplex. This review summarizes the current research progress of ARC in the field of tumorigenesis and ischaemia/reperfusion injury, to provide overall research status and new possibilities for researchers.

Address: Department of Immunology, Zunyi Medical University, 563000, Zunyi, China.; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, 563000, Zunyi, China.; Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, 563000, Zunyi, China.; Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, 563000, Zunyi, China.; Department of Histology and Embryology, Zunyi Medical University, 563000, Zunyi, China. [email protected].; Department of Immunology, Zunyi Medical University, 563000, Zunyi, China. [email protected].; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, 563000, Zunyi, China. [email protected].; Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, 563000, Zunyi, China. [email protected].

DOI: 10.1007/s10495-022-01802-4

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https://doi.org/10.1007/s10495-022-01802-4

MeSH Terms: Humans, Apoptosis, Apoptosis Regulatory Proteins, Caspase Activation and Recruitment Domain, Reperfusion Injury, Carcinogenesis, Cell Transformation, Neoplastic, Reperfusion