Two New Enantiomers of Phenylethanoid and Their Anti-Inflammatory Activities.

Qi Jia, Pei-Yuan Yang, Ya-Ling Li, Guo-Dong Yao, Shao-Jiang Song, Xiao-Xiao Huang

Journal: Chemistry & biodiversity 2023;20(4):e202300067

PMID: 36810976

Abstract

In this phytochemical investigation, two pairs of new phenylethanoid derivative enantiomers (1a/1b and 2a/2b), a new phenylethanoid derivative 3b, and seven known compounds (3a, 4-9) were isolated from the leaves of Picrasma quassioides. Spectroscopic techniques were used for the elucidation of their chemical structures, and the absolute configurations were determined by a comparison between the experimental and calculated ECD data, as well as the application of Snatzke's method. Compounds (1a/1b-3a/3b) were measured for their production of NO levels in LPS-induced BV-2 microglial cells. The results showed that all compounds exhibited potential inhibitory effects, and compound 1a showed stronger activity than the positive control.

Address: Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China.

DOI: 10.1002/cbdv.202300067

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https://doi.org/10.1002/cbdv.202300067

MeSH Terms: Anti-Inflammatory Agents, Microglia, Molecular Structure, Spectrum Analysis, Stereoisomerism, Phenylethyl Alcohol