Microbes, oxytocin and stress: Converging players regulating eating behavior.

Cristina Cuesta-Marti, Friederike Uhlig, Begoña Muguerza, Niall Hyland, Gerard Clarke, Harriët Schellekens

Journal: Journal of neuroendocrinology 2023;35(9):e13243

PMID: 36872624

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Abstract

Oxytocin is a peptide-hormone extensively studied for its multifaceted biological functions and has recently gained attention for its role in eating behavior, through its action as an anorexigenic neuropeptide. Moreover, the gut microbiota is involved in oxytocinergic signaling through the brain-gut axis, specifically in the regulation of social behavior. The gut microbiota is also implicated in appetite regulation and is postulated to play a role in central regulation of hedonic eating. In this review, we provide an overview on oxytocin and its individual links with the microbiome, the homeostatic and non-homeostatic regulation of eating behavior as well as social behavior and stress.

Address: Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland.; APC Microbiome Ireland, Cork, Ireland.; Department of Physiology, University College Cork, Ireland.; Universitat Rovira i Virgili, Department of Biochemistry & Biotechnology, Nutrigenomics Research Group, Tarragona, Spain.; Department of Psychiatry & Neurobehavioural Science, University College Cork, Cork, Ireland.

DOI: 10.1111/jne.13243

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MeSH Terms: Oxytocin, Feeding Behavior, Peptide Hormones, Neuropeptides, Appetite Regulation, Eating, Brain