Esmethadone-HCl (REL-1017): a promising rapid antidepressant.

Address: Department of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Psychiatry, VAMC (SD), University of California, San Diego, La Jolla, CA, 92093, USA.; Neuroscience Education Institute, Carlsbad, CA, 92008, USA.; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35122, Padua, Italy.; In Vitro Pharmacology Department, Aptuit, an Evotec Company, 37135, Verona, Italy.; Department of Biomedical Sciences, University of Padua, 35122, Padua, Italy.; Department of Psychiatry, McGill University, Montreal, QC, H3A 1A1, Canada.; Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland.; Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), 6500, Bellinzona, Switzerland.; Università della Svizzera Italiana, 6900, Lugano, Switzerland.; Veneto Institute of Molecular Medicine, 35129, Padua, Italy.; Department of Medicine-DIMED, University of Padua, 35122, Padua, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, 20122, Milan, Italy.; Relmada Therapeutics, Coral Gables, FL, 33134, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Miami, Miami, FL, 33146, USA.; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41121, Modena, Italy.; Department of Health Sciences, University of Milan, 20122, Milan, Italy.; Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Pediatric Hospital, 00165, Rome, Italy.; Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland.; Relmada Therapeutics, Coral Gables, FL, 33134, USA. [email protected].