Is the mitochondrial ATP synthesis solely H-driven, K,H symport-driven or K/H antiport-driven?

Victor V Lemeshko

Journal: Biochimica et biophysica acta. Biomembranes 2023;1866(1):184229

PMID: 37704041

Abstract

Some recent literature experimental data indicate that the mitochondrial ATP synthesis might be not solely H-driven, but K,H symport-driven membrane potential-dependent, considered as a further development of Mitchell's chemiosmotic theory, in contrast to the anti-Mitchell's hypothesis of K/H antiport-driven mechanism. In this short communication, the attention was pointed to a possible influence of the ionic strength of the used KCl incubation medium, versus of only K ions, and of the Mg-induced mitochondrial aggregation in the sucrose medium on the reported rates of the mitochondrial respiration and ATP synthesis. These observations were based on the own author's experimental works published earlier.

Copyright © 2023 Elsevier B.V. All rights reserved.

Address: Escuela de Física, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Medellín, Carrera 65, Nro. 59A - 110, Medellín, Colombia. Electronic address: [email protected].

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