Victor V Lemeshko
Journal: Biochimica et biophysica acta. Biomembranes 2023;1866(1):184229
PMID: 37704041
Some recent literature experimental data indicate that the mitochondrial ATP synthesis might be not solely H-driven, but K,H symport-driven membrane potential-dependent, considered as a further development of Mitchell's chemiosmotic theory, in contrast to the anti-Mitchell's hypothesis of K/H antiport-driven mechanism. In this short communication, the attention was pointed to a possible influence of the ionic strength of the used KCl incubation medium, versus of only K ions, and of the Mg-induced mitochondrial aggregation in the sucrose medium on the reported rates of the mitochondrial respiration and ATP synthesis. These observations were based on the own author's experimental works published earlier.
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