Discordant skeletal muscle gene and protein responses to exercise.

David J Bishop, Nolan J Hoffman, Dale F Taylor, Nicholas J Saner, Matthew J-C Lee, John A Hawley

Journal: Trends in biochemical sciences 2023;48(11):927-936

PMID: 37709636

Full Text on Elsevier Science View on PubMed

Abstract

The ability of skeletal muscle to adapt to repeated contractile stimuli is one of the most intriguing aspects of physiology. The molecular bases underpinning these adaptations involve increased protein activity and/or expression, mediated by an array of pre- and post-transcriptional processes, as well as translational and post-translational control. A longstanding dogma assumes a direct relationship between exercise-induced increases in mRNA levels and subsequent changes in the abundance of the proteins they encode. Drawing on the results of recent studies, we dissect and question the common assumption of a direct relationship between changes in the skeletal muscle transcriptome and proteome induced by repeated muscle contractions (e.g., exercise).

Address: Institute for Health and Sport (iHeS), Victoria University, Melbourne, Australia. Electronic address: [email protected].; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.; Institute for Health and Sport (iHeS), Victoria University, Melbourne, Australia.

DOI: 10.1016/j.tibs.2023.08.005

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MeSH Terms: Muscle, Skeletal, Exercise, Transcriptome, Muscle Contraction, Proteome