History of Changes in the Protocol of Clinical Trial of Zinc Supplementation in Treatment of COVID-19 by Hydroxychloroquine.

Dorn Sornsil, Kouji H Harada, Arthit Phosri

Journal: Biological trace element research 2024;202(5):1926-1927

PMID: 37572184

Abstract

An article published in this journal used a randomized controlled trial to evaluate the efficacy of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. Findings from this study indicate that zinc supplements did not enhance the clinical efficacy of hydroxychloroquine in improving COVID-19 treatment. Although this finding is consistent with many previous studies, several concerns regarding study protocol and trial registration, including interventions and primary outcomes, have been raised in which the protocol has been changed after the completion of the recruitment.

Address: Department of Social Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, 6068501, Japan. [email protected].; Department of Health Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Environmental Health Sciences, Faculty of Public Health, Mahidol University, Bangkok, Thailand.

DOI: 10.1007/s12011-023-03807-9

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https://dx.doi.org/10.1007/s12011-023-03807-9

MeSH Terms: Humans, Antiviral Agents, COVID-19, COVID-19 Drug Treatment, Dietary Supplements, Hydroxychloroquine, SARS-CoV-2, Treatment Outcome, Zinc, Clinical Trial Protocols as Topic